Molecular Neuro-degeneration Essay Example | Topics and Well Written Essays - 1500 words

Molecular Neuro-degeneration - Essay Example It is evident that no drug has been discovered that could to completely protect neurons; there are two possible approaches to that may come up with the treatment of AD. One approach involves treatment which prevents the onset of the disease through curbing the primary targets and reducing the subsequent pathologies of the AD. This way, it becomes possible to slow the disease progression and hence prevention to the development of AD (Vradenburg 2013). The second approach involves the symptomatic treatment; an approach whereby the primary and tertiary symptoms of the AD are declined. Through this approach, reflection to the current state of treatment including the usual treatment the cognitive impairment, the decline in global function, deteriorating performance of activities of daily living and behavioral change ( Perry 2013). When searching for the appropriate treatment strategies, scientists concentrate on the severity of the disease and also the specificity of each individual. Currently the available therapeutic agents are the main target to specific symptoms of the AD; the agents such as cholinesterase inhibitors involved in the enhancement of cholinergic neurotransmission and also the inhibiting of acetylcholine degradation within the synapse are the Alzheimer’s disease main treatment (Vradenburg 2013). Going by the report on the role of the involvement of PI3 kinase signaling in AÃŽ ²-induced memory loss in Drosophila, the PI3K-Akt-mTOR pathway regulation in AÃŽ ² oligomer neuronal cell cycle process and Amyloid-b Interruption of the PI3K-Akt-mTOR signaling pathway involvement in brain-derived neurotrophic factor-induced arc expression in rat scientists can improve theirs unleash a further superior drug to completely heal the Alzheimer’s disease (Perry 2013). One of the hindrances to the progress of other researchers on AD have been due to the fact that most drugs developed show general success in animal specimens but when testing them to human beings, they become less responsive, Therefore, it is safe to say that this project is still in its infancy and further studies have to be carried out but in the long run a solution will be arrived upon.

Contextualization of the Archaeology of Qumran and the Dead Sea Essay

Contextualization of the Archaeology of Qumran and the Dead Sea Scrolls - Essay Example In the aftermath of de Vaux’s excavations in the 1950’s up until the mid 1980’s, it has been commonly assumed that the Dead Sea Scrolls discovered in the nearby caves constituted the library of a Jewish sectarian community (most probably of the Essene sect that lived at Qumran). However, despite such apparent consensus, we ought not to narrowly focus our interpretation of the Scrolls, its authors (for which most scholars seem to agree are the Essenes) and the Qumran site itself when it comes to a proper analysis of contextualizing all three. In light of recent scholarship, the traditional sectarian explanation of Qumran combined with a more nuanced approach may possibly reveal that the site had at least a dual purpose beyond that of a certain sectarian settlement and more specifically was a place for the development of communal activities, including the production or manufacture of pottery. Moreover, could it have been possible that the Essenes employed non-Essen es to do certain functions? To be certain, it has long been argued since de Vaux’s excavation reports, that when placed in a proper historical and archaeological context, the caves, the scrolls and the ruins are altogether interconnected.To shed some historical perspective, according to Davies, Brooke and Callaway, the basis for this interconnectivity was originally the texts themselves found in Cave 1 and their later interpretation by de Vaux’s team of excavators, the members of the Cave 4 editorial team and most other scholars